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When the menopause arrives before 45

The age at which your periods stopped is a health fact, not a curiosity. Before 45 — and especially before 40 — it changes what is worth keeping an eye on, and it is information your doctor is glad to have.

5 min read

1.5 to 3×

the fracture risk when the menopause happens at 45 or earlier, compared with after 50

International guideline on premature ovarian insufficiency (ESHRE/ASRM/IMS), 2025

≈ 1%

of women have their last period before the age of 40

National Institute for Health and Care Excellence (NICE), NG23

Two boundaries that count

The international guidelines distinguish two cases. Early menopause, when the last period happened before the age of 45. And premature ovarian insufficiency, when it happened before 40 — which affects about 1% of women and has its own follow-up.

The difference between the two is not one of tone, it is one of management: before 40 there is a specific approach set out in the guidelines; between 40 and 44 there is a fact to take into account when prevention is discussed.

What the numbers say

The international guideline on premature ovarian insufficiency, written jointly by four scientific societies, gathers what is known. A menopause at 45 or earlier is associated with a fracture risk between one and a half and three times that of a menopause after 50.

For the heart the signal is quieter but real: in women with premature ovarian insufficiency, cardiovascular events appear about 1.3 to 1.4 times more often than in those whose menopause came between 50 and 54.

These are associations from population studies, not an individual verdict. What they justify is attention, not worry.

What to do with it

The first step is the simplest and the most forgotten: tell your doctor the age at which your periods stopped. It is a fact that is rarely asked for and that changes how your risk reads.

From there, three topics are worth raising: bone health, cardiovascular health, and — where the menopause came before 40 — hormone therapy, which the international guidelines recommend considering until the usual age of menopause, unless contraindicated. That decision belongs to your doctor and is individual; your part is making sure the topic reaches the table.

It is not a reason to be alarmed

It is worth keeping this in proportion:

  • An earlier menopause is not a disease and does not determine what will happen to you — it is one factor among several.
  • Each year earlier in the age at menopause is associated with a small increase in cardiovascular risk, and that is what helps personalise prevention.
  • If you do not know the exact age, that is fine: knowing it was "before 40" or "between 40 and 45" is enough for the conversation.
  • Take the EasyCheckUp to bring this fact, and what it changes, organised for the appointment.

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